Stem cell exosomes and their functions

Exosomes are membrane-bound vesicles that resemble tiny packages and transport substances between cells. They are produced within cells and then released to move in the intercellular environment. These microvesicles represent a form of communication between cells; they are like letters exchanged between them. Exosomes are thought to be powerful mediators: they transmit the signals that trigger the necessary mechanisms to change the behavior of other cells. 

When used therapeutically, exosomes have the following properties:

  • they activate differentiation (the process by which cells acquire certain functions);
  • they stimulate proliferation (cell division in tissue);
  • they regulate the regeneration process;

These properties can help treat aging-related skin changes, hair loss, and numerous diseases that involve damage to various types of tissue (e.g., skin, muscles, nerves, and specific organ tissues).

ASCEplus SRLV​

ASCEplus SRLV is recommended for:

  • Skin with weak regenerative ability
  •  Unbalanced skin with big pores and redness
  •  Acne skin with acne scars
  • Sensitive and thin skin by nature or other environmental reasons including frequent procedures
  •  Skin with other inflammatory skin diseases such as atopic dermatitis, rosacea
    ASCEplus SRLV is NOT recommended for
  •  Skin with great regeneration ability
  •  Artificial volumizing effect
  •  Temporary improvement in deep wrinkles

ASCEplus SRLV - Acne Skin Trouble

  • Protocol: Week 1:1 peeling with glycolic acid / 
  • Week 2: Mesotherapy 
  • Week 4: Mesotherapy + dermapen 4 superficial
Before
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1 session after
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After
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ASCEplus SRLV - Aged Skin

  • Protocol: applied after RF needle treatment
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After
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FAQ

What exactly is an exosome?

• Exosome is a nano-sized endoplasmic reticulum secreted by the cell outside its walls for information exchange between cells, a core substance for inter-cell signal delivery. Exosome plays the role of delivering biologically active substances befitting various cell functions to receptor cells, which is why exosomes are called the "avatar" of the cell.
• All cells possess exosomes, but the stem cell exosome in particular is the main agent ingredient of the stem cell's Paracrine effect that gives the stem cell ability to regenerate.
• Paracrine Effect: As one of the important regeneration functions of stem cell, it regenerates and treats damaged cells nearby

Does ASCEplus SRLV contain any other ingredients besides exosome?

• The first vial of ASCEplus SRLV includes various active ingredients such as 5 types of growth factors, 6 types of peptides, glutathione, and more aside from rose stem cell exosomes.
• Type 2 includes hyaluronic acid, 4 types of growth factors, etc. that can maximize synergistic effects when combined with type 1, which altogether enhances overall skin condition through skin generation, anti-oxidation, and dermatitis improvement.

Is this a manual process? Or is it a procedure that is combined with the laser?

•Exosomen werden durch oberflächliches Microneedeling eingearbeitet. Dieser Eingriff ist kaum schmerzhaft und gut verträglich

For which patient is this procedure most effective?

• Anyone who wishes to find a comprehensive skincare that uses skin generation to improve elasticity, fine wrinkles, pores, etc.
• Anyone who wishes to improve irritated, reddened skin such as skin with dermatitis, face flush, etc.
• Anyone who wishes to improve troubled skin caused by wearing masks
• Zur Anregung des Haarwuchses

Time for results to appear: Can you see results immediately?

• This depends on the skin condition of each individual, but if the product was applied through meso therapy, you can see your skin become one tone brighter and gain watery glow about 2-3 days after only one procedure. More amplified effects can be expected after the 5-time procedure package.
(SRLV contains 1,600,000 daltons of HA, which boost immediate watery glow as well as long-term sustaining power.)

How long does the effect last?

• This depends on the skin condition of each individual, but the effects last for about 1 month after one instance of procedure.
• For a noticeable effect, we recommend at least 3 rounds of treatment; after the basic package 5 times,
You can have the procedure every 6 months to 1 year to maintain healthy skin.
(This product does not have an artificial duration like Botox or fillers, as this skin care solution is all about restoring your skin to its original, healthy state naturally. Therefore, the duration of effects may vary depending on the person and environment. )
The content of this section is limited to the properties of the raw materials. SRIV is a stem cell culture medium containing these raw materials.

How is it different from other skin booster products?

• Existing skin booster products in the market provide skin with moisture and nutrients.
• However, ASCEplus SRLV not only strengthens the skin barrier but also improves the condition of the dermis and subcutaneous tissue by increasing collagen synthesis and elastin in a human-friendly way. As a result, the product changes the basic condition of the skin.

How is it different from other culture medium or exosome products?

• Not all culture media are the same and not all exosomes are the same.
• ExoCoBio's exosomes contain PRDXs, a protein proven to have anti-aging and skin regeneration effects, and let-7b, one of the miRNAs shown to have anti-inflammatory effects through clinical studies and theses. In addition, one of the exosome markers CD44 enables the delivery of active ingredients to the skin. These factors are proven by scientific studies.

How do other hospitals promote and market the product?

• ASCEplus SRLV is introduced as a 4th generation skin booster that allows you to experience skin building, anti-inflammatory and other various effects at the same time. It is also recommended for those who are dissatisfied with conventional skin enhancers already available on the market.
• In addition, there is a lot of ongoing research abroad into exosome-based drugs as a possible treatment for cancer or other rare diseases. Particularly in the area of ​​regenerative aesthetics, there is extensive active research to prove its effectiveness, and ExoCoBio's own articles and clinical studies also prove its effectiveness.

How long is the interval between procedures? How often do you have to undergo a procedure?

• We recommend performing the procedure 5 times at an interval of 2 weeks. The minimum number of treatment rounds we recommend is 3 times. • There are hospitals that allow the patient to undergo the procedure once a week if they wish, and there are a growing number of patients who receive even more than 5 procedures, up to 7 or 8 procedures. The reason for this is the great satisfaction that these procedures bring with them. Patients have experienced the results of the procedure.

How should ASCEplus SRLV be stored?

• ASCEplus SRLV must be kept refrigerated at a temperature between 2 and 8 degrees Celsius.
• We recommend using the freeze-dried powder mixture within 3 hours to ensure stability.

Can I mix it with other products?

In the case of ASCEplus SRLV, we recommend its use alone as the first and second vials are designed for the optimal rate.

Our treatments:

Eyelids: Blepharoplasty (upper and lower eyelid lift), ptosis (drooping eyelid), entropion (inward turning of the eyelid margin), ectropion (senile and scar-related outward turning of the eyelid), reconstruction of the eyelids.

-  Tired or watery eyes can be the result of excess skin or misalignment of the eyelids.

Face: Brow and forehead lift, face and neck lift (from minimally invasive to classic), ear augmentation, nose correction, removal of benign and malignant skin and subcutaneous tumors and subsequent reconstruction.

Hand: Carpal tunnel syndrome, trigger finger, wrist ganglion, Dupuytren contracture.

Body: Breast enlargements with your own fat or silicone implants, breast reductions and lifts, reconstructive breast and nipple corrections, liposuction (laser, ultrasound and water-assisted treatments are possible), body shaping with lipofilling, where the fat is converted into micro/nano and SVF-enriched own fat, Tightening of any area of ​​the body e.g. E.g. tummy tuck, upper arm and thigh lift, female intimate surgery

Plastic surgery and aesthetic medicine

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